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The Connective Tissue Research Group is a Tennessee Center of Excellence.

 

Andrew H. Kang, M.D. is the director of the center of excellence for diseases of connective tissues.  Associate directors are Arnold Postlethwaite, M.D. and Dennis Schaberg, M.D. This Center of Excellence is a comprehensive center for basic clinical and translational research, education and training and community outreach for the State of Tennessee in diseases affecting the joints, cartilage, skeleton and connective tissues of the body. The categories of disease the center addresses include classic arthritis associated immune based rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, rheumatic fever), degenerative joint disease including the intervertebral discs, osteoporosis, scleroderma and related fibrosing diseases. Components groups study etiologic and pathogenetic mechanisms of these diseases using of animal models and in vitro cell culture systems, development of new diagnostic tests and develop new therapies and prosthetics to treat these diseases. The center is also a hub for education and training of pre- and post-doctoral fellows in the arthritides and related diseases and has outreach programs to better educate private physicians in Tennessee and the public about arthritis, bone, joint and connective tissue diseases.
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Research Trials

To view the University of Tennessee Health Science Center and National Institutes of Health (NIH) sponsored research trials involving patients with rheumatoid arthritis or scleroderma please see the links below.

 Rheumatoid Arthritis:

http://clinicaltrials.gov/ct/gui/show/NCT00000401?order=5&JServSessionIdzone_ct=qr8jb52941

Scleroderma:

http://clinicaltrials.gov/ct/gui/show/NCT00005675?order=1&JServSessionIdzone_ct=y4w6gv26i1

 Data from Oral tolerance trials

Supplemental Table III.  Adverse Events and Deaths in Patients with SSc Enrolled in the Study

Supplemental Table II.  Changes in Clinical Parameters at 12 Months and 15 Months Using Available Data


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Tweak the mouse to view short primer on the induction of experimental arthritis with type II collagen

(from our chapter submitted to Current Protocols in Immunology


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For questions/comments, please call David Brand at (901) 577-7282.

Page Last Updated: 10/04/2007